In 1980, the decision is made to consolidate all parish operations to one side of Avenue O. Recognizing the shifting demographic trends in the neighborhood, it is proposed that a housing complex for senior citizens be developed. Although it will take some years before all of the technicalities are worked out, the "new" school building and the "new" convent, located across Avenue O from the church and the "old" school building, are demolished, in anticipation of the eventual development of the land. This will come to fruition in 1987, with the opening of the "St. Brendan's Houses". Administered by Catholic Charities of Brooklyn and Queens, the "St. Brendan's Houses", while completely separate and detached from the parish in any operational sense, is perhaps intangibly linked in a certain historical-emotional sense.
Anticipating the parish's 75th Anniversary in 1982, and recognizing the need for a number of structural improvements, the decision is made to renovate the church interior during 1981. A feasibility study is headed by Jack McGrath, and Howard "Doc" Parsons oversees the fundraising drive. The last Mass in the pre-renovated sanctuary is offered on Christmas 1980. During construction, Mass is held in the school auditorium. The renovated sanctuary, which incorporated existent assets in conjunction with new assets and materials, is unveiled on Palm Sunday 1981. The space is then rededicated by the Most Reverend Francis J. Mugavero, fifth Bishop of Brooklyn, on Pentecost 1981.
All of the renovation and reorganization served to re-energize the clergy and the people of St. Brendan. Fathers Villani and Finnerty began the "Pope John XXIII Forum", which sponsored lectures and debates featuring notable speakers who addressed contemporary issues facing the church. Rev. Peter Vaccari, later to become the rector of the seminaries at Huntington and Dunwoodie, began a drama group, whose first performance was a Meditation on the Passion of Christ during the 1983 Lenten season, succeeded over the years by productions of L'il Abner, West Side Story, Grease, 1776, and Damn Yankees. Also in the Eighties, the Men's Club presented the parish with a bronze memorial honoring those men and women from St. Brendan who served in the armed forces.
The parish celebrated its 75th anniversary in October 1982, with a Mass of Thanksgiving celebrated by Bishop Mugavero, joined by over 50 concelebrants. A dinner-dance followed at El Caribe Country Club.
In 1985, Fr. O'Grady officially retired. Fr. Villani, who had served as Administrator since 1979, was named as the sixth pastor of St. Brendan's. Fr. Villani, having done so much already as parochial vicar and administrator, continued expanding the opportunities for engagement, notably instituting a Lenten Soup Supper.
In 1988, Fr. Villani was transferred to Mary Mother of Jesus, and Rev. James B. McMahon was named as seventh pastor of St. Brendan's. Like Fr. Villani, Fr. McMahon also comes to the parish from having worked at Cathedral College. In 1989, he is made a Monsignor.