In 326, St. Helena, the mother of the Emperor Constantine, ordered the development of a Church on the land surrounding Calvary. During the excavations, three crosses were found. Under the supervision of the Bishop of Jerusalem, St. Macarius, the three crosses were laid upon the body of a woman near death. The touch of the first two crosses proved to be of no avail, but upon touching the third cross, the woman was instantly healed.

Following additional excavations, the tomb where Jesus' body was interred by Joseph of Arimethea was also found. Both sites were incorporated into the overall church structure, know to us as the Church of the Holy Sepulchre.

A Third Century martyr, St. Barbara was locked away in a tower by her pagan father. Upon discovering that she was a Christian, her father reported her to the authorities. She spent an extended time in prison, during which she was tortured, but her wounds would mysteriously heal by the following morning. Eventually, St. Barbara was sentenced to death, her father assigned to be her executioner; this window depicts that event. Following the execution, her father was struck by lightning and his body burned away; this story has led to St. Barbara's patronage of artillerymen, who seek the saint's intercession in avoiding the fate of her father.

St. Anthony had been an Augustinian friar before joining a Franciscan monastery. His renown as a preacher and author, and the quality of the works which have survived through the centuries after his death, led to his being declared a Doctor of the Church by Pope Pius XII in 1946.

Founder of what is now referred to as the Franciscan Orders, St. Francis is also famous for the creation of the first Nativity creche, and for his patronage of animals. This window depicts St. Francis receiving the stigmata, the wounds of Christ on the Cross, shortly before the end of his life.